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排序方式: 共有85条查询结果,搜索用时 36 毫秒
61.
Robert Hoffman 《Environmental monitoring and assessment》1992,20(2-3):175-177
62.
Kenow KP Hoffman DJ Hines RK Meyer MW Bickham JW Matson CW Stebbins KR Montagna P Elfessi A 《Environmental pollution (Barking, Essex : 1987)》2008,156(3):732-738
We quantified the level of dietary mercury (Hg), delivered as methylmercury chloride (CH3HgCl), associated with negative effects on organ and plasma biochemistries related to glutathione (GSH) metabolism and oxidative stress, and chromosomal damage in captive-reared common loon (Gavia immer) chicks reared from hatch to 105 days. Mercury-associated effects related to oxidative stress and altered glutathione metabolism occurred at 1.2 μg Hg/g and 0.4 μg Hg/g, an ecologically relevant dietary mercury level, but not at 0.08 μg Hg/g. Among the variables that contributed most to dissimilarities in tissue chemistries between control and treatment groups were increased levels of oxidized glutathione (GSSG), GSH peroxidase, and the ratio of GSSG to GSH in brain tissue; increased levels of hepatic GSH; and decreased levels of hepatic glucose-6-phosphate dehydrogenase (G-6-PDH). Our results also suggest that chronic exposure to environmentally relevant dietary Hg levels did not result in statistically significant somatic chromosomal damage in common loon chicks. 相似文献
63.
Ghosh S Zang S Mitra PS Ghimbovschi S Hoffman EP Dutta SK 《Environment international》2011,37(5):838-857
Several reports have indicated that low level of polychlorinated biphenyl (PCB) exposure can adversely affect a multitude of physiological disorders and diseases in in vitro, in vivo, and as reported in epidemiological studies. This investigation is focused on the possible contribution of two most prevalent PCB congeners in vitro in developing toxicities. We used PCBs 138 and 153 at the human equivalence level as model agents to test their specificity in developing toxicities. We chose a global approach using oligonucleotide microarray technology to investigate modulated gene expression for biological effects, upon exposure of PCBs, followed by Ingenuity Pathway Analysis (IPA), to understand the underlying consequence in developing disease and disorders. We performed in vitro studies with human peripheral blood mononuclear cells (PBMC), where PBMC cells were exposed to respective PCBs for 48 h. Overall, our observation on gene expression indicated that PCB produces a unique signature affecting different pathways, specific for each congener. While analyzing these data through IPA, the prominent and interesting disease and disorders were neurological disease, cancer, cardiovascular disease, respiratory disease, as well as endocrine system disorders, genetic disorders, and reproductive system disease. They showed strong resemblances with in vitro, in vivo, and in the epidemiological studies. A distinct difference was observed in renal and urological diseases, organisimal injury and abnormalities, dental disease, ophthalmic disease, and psychological disorders, which are only revealed by PCB 138 exposure, but not in PCB 153. The present study emphasizes the challenges of global gene expression in vitro and was correlated with the results of exposed human population. The microarray results give a molecular mechanistic insight and functional effects, following PCB exposure. The extent of changes in genes related to several possible mode(s) of action highlights the changes in cellular functions and signaling pathways that play major roles. In addition to understanding the pathways related to mode of action for chemicals, these data could lead to the identification of genomic signatures that could be used for screening of chemicals for their potential to cause disease and developmental disorders. 相似文献
64.
Albers PH Hoffman DJ Buscemi DM Melancon MJ 《Environmental pollution (Barking, Essex : 1987)》2003,125(3):447-451
Golden Bear Oil (GB-1111; legal trade name for GB-1313) is a petroleum distillate that is used in the United States and other countries as a larvicide for mosquito suppression. As part of a multi-species evaluation of the potential effects of GB-1111 on birds, red-winged blackbird eggs were collected, artificially incubated, and treated with one of five amounts of GB-1111 varying from 0 to 10 times the expected exposure from a spray application of the maximum recommended amount (X=47 l/ha, 5 gal/ac). The application of 10 X caused a significant reduction in hatching success. A dose-related reduction of hepatic microsomal monooxygenase activity (EROD) was detected. Among body weights, skeletal measurements, and age at death, only crownrump length was different among experimental groups. Overall, the potential hazard to embryos of a representative wetland passerine appears minimal until the application rate exceeds 3 X. 相似文献
65.
James S. Latimer Constance G. Carey Eva J. Hoffman James G. Quinn 《Journal of the American Water Resources Association》1988,24(4):791-800
ABSTRACT: The Pawtuxet River flows from a relatively rural area through some of the more highly industrialized sections of Rhode Island. During its journey, the river receives many municipal, industrial, and ground water sources of metal constituents. The present report is the first in a two part series in which the water quality of this urban river was evaluated by a chemical monitoring study of the sources, transport mechanisms, and fate of cadmium, chromium, copper, lead, and nickel in the river. The second paper will use the chemical data to derive and calibrate a steady-state water quality model for this river. The metal concentrations In the river tended to increase from the headwaters to the mouth with river stations nearest to point source outfalls showing elevated values. In some sections of the river, levels of a few of the metals could not be explained by the point sources; and other inputs, including sediment resuspension, axe proposed to make up this apparent unbalance. The ability of a municipal secondary treatment plant to remove metals was demonstrated, and the tie-in of the effluent from a major chemical company to the plant did not cause any observable deterioration in treatment efficiency. 相似文献
66.
Rattner BA Flickinger EL Hoffman DJ 《Environmental pollution (Barking, Essex : 1987)》1993,79(1):85-93
Male cotton rats (Sigmodon hispidus) were studied at three industrial waste sites near Houston, Texas, to determine whether various morphological, biochemical, and histopathological indices provided evidence of contaminant exposure and toxic insult. Only modest changes were detected in cotton rats residing at waste sites compared with reference sites. No single parameter was consistently altered, except hepatic cytochrome P-450 concentration which was lower ( [Formula: see text] ) at two waste sites, and tended to be lower ( [Formula: see text] ) at a third waste site. Elevated petroleum hydrocarbon concentrations were detected in rats at one waste site, but contaminant burdens of rats from the other sites were unremarkable. Unlike rats captured in summer, those trapped in winter exhibited hepatocellular hypertrophy and up to a 65% increase in liver: body weight ratio, cytochrome P-450 concentration, and activities of aniline hydroxylase, aryl hydrocarbon hydroxylase, and glutathione S-transferase. Although genotoxicity has been previously documented in cotton rats residing at two of the waste sites, biomarkers in the present study provided little evidence of exposure and damage. 相似文献
67.
DNA Repair Activity and Resistance to Solar UV-B Radiation in Eggs of the Red-legged Frog 总被引:2,自引:0,他引:2
Andrew R. Blaustein Peter D. Hoffman Joseph M. Kiesecker John B. Hays 《Conservation biology》1996,10(5):1398-1402
We assessed DNA repair and resistance to solar radiation in eggs of the red-legged frog (Rana aurora) , a species whose populations appear to be in decline. Specifically, we measured the activity of photoreactivating enzyme, photolyase, in R. aurora oocytes. In some species photoreactivation is the most important mechanism for repair of UV-damaged DNA. We also compared the hatching success of R. aurora eggs subjected to ambient levels of UV-B radiation with those shielded from UV-B radiation. We found photolyase levels in R. aurora to be relatively high when compared with other amphibians and hatching success to be unaffected by UV-B radiation. We suggest that UV-B radiation is an unlikely cause for declining populations of red-legged frogs. 相似文献
68.
R. L. Schmoyeri J. J. Beauchamp C. C. Brandt F. O. Hoffman Jr 《Environmental and Ecological Statistics》1996,3(1):81-97
A frequent assumption in environmental risk assessment is that the underlying distribution of an analyte concentration is lognormal. However, the distribution of a random variable whose log has a t-distribution has infinite mean. Because of the proximity of the standard normal and t-distribution, this suggests that a distribution such as the gamma or truncated normal, with smaller right tail probabilities, might make a better statistical model for mean estimation than the lognormal. In order to assess the effect of departures from lognormality on lognormal-based statistics, we simulated complete lognormal, truncated normal, and gamma data for various sample sizes and coefficients of variation. In these cases, departures from lognormality were not easily detected with the Shapiro-Wilk test. Various lognormal-based estimates and tests were compared with alternate methods based on the ordinary sample mean and standard error. The examples were also considered in the presence of random left censoring with the mean and standard error of the product limit estimate replacing the ordinary sample mean and standard error. The results suggest that in the estimation of or tests about a mean, if the assumption of lognormality is at all suspect, then lognormal-based approaches may not be as good as the alternative methods. 相似文献
69.
Donald H. White Clifford P. Rice David J. Hoffman George F. Gee 《Environmental monitoring and assessment》1994,31(3):225-232
Our objectives were to determine if concentrations of environmental pollutants and microbial contamination in nonviable eggs of the endangered Mississippi sandhill crane (Grus canadensis pulla) contributed to egg failure. Six eggs collected in 1990 and four in 1991 contained only background levels of organochlorine pesticides and polychlorinated biphenyls (PCBs), and tests for microbial contamination were all negative. Two eggs contained late dead embryos, but neither revealed obvious abnormalities. Three eggs contained potentially harmful concentrations (23, 39, 146 pg/g, wet mass) of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), based on 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TCDD-EQ) for combined compounds. Because of the scarcity of material suitable for laboratory examination and the endangered status of the crane, we recommend that nonviable eggs continue to be monitored for toxic pollutants. 相似文献
70.
Christy L. Hoffman Angelina V. Ruiz-Lambides Edgar Davila Elizabeth Maldonado Melissa S. Gerald Dario Maestripieri 《Behavioral ecology and sociobiology》2008,62(11):1711-1718
In sexually promiscuous mammals, female reproductive effort is mainly expressed through gestation, lactation, and maternal
care, whereas male reproductive effort is mainly manifested as mating effort. In this study, we investigated whether reproduction
has significant survival costs for a seasonally breeding, sexually promiscuous species, the rhesus macaque, and whether these
costs occur at different times of the year for females and males, namely in the birth and the mating season, respectively.
The study was conducted with the rhesus macaque population on Cayo Santiago, Puerto Rico. Data on 7,402 births and 922 deaths
over a 45-year period were analyzed. Births were concentrated between November and April, while conceptions occurred between
May and October. As predicted, female mortality probability peaked in the birth season whereas male mortality probability
peaked in the mating season. Furthermore, as the onset of the birth season gradually shifted over the years in relation to
climatic changes, there was a concomitant shift in the seasonal peaks of male and female mortality. Taken together, our findings
provide the first evidence of sex differences in the survival costs of reproduction in nonhuman primates and suggest that
reproduction has significant fitness costs even in environments with abundant food and absence of predation. 相似文献